Sanjay Sethi, MD
Medicine
Professor and Chief, Pulmonary, Critical Care and Sleep Medicine; Vice Chair for Research
VA WNY Healthcare System
3495 Bailey Avenue
Buffalo, NY 14215
Phone: (716) 862-7875
Fax: (716) 862-6526
Email: ssethi@buffalo.edu
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OFFICE LOCATIONS
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VA Medical Center 3495 Bailey Ave Buffalo, NY 14215 Phone: 862-7874 Fax: 862-6526 Contact: Cookie Thurston Email: sethi.sanjay@buffalo.va.gov View Map |
DESCRIPTION OF INTERESTS
| Sanjay Sethi, MD, FACP, is a Professor in the Department of Medicine at the University of Buffalo at the State University of New York (SUNY) where he also completed a fellowship in pulmonary and critical care medicine. He is the Chief of the Division of Pulmonary/Critical Care/Sleep Medicine at the University at Buffalo and the Section Chief for Pulmonary/Critical Care/Sleep Medicine at the Western New York Veterans Administration HealthCare System in Buffalo. Dr Sethi completed his internship and residency in internal medicine at Cook County Hospital in Chicago, Illinois and is board certified in internal medicine, pulmonary disease, and critical care medicine. Dr Sethi’s main research interests include respiratory infections and chronic obstructive pulmonary disease, focused on the specific areas of bacterial infection in COPD, epidemiology and clinical implications of antimicrobial resistance and innate lung defense in COPD. Dr Sethi’s has co-authored more than a 100 research articles and reviews in many peer-reviewed medical journals including New England Journal of Medicine, American Journal of Respiratory and Critical Care Medicine, Chest, COPD: Journal of Chronic Obstructive Pulmonary Disease, Infection and Immunity, Journal of Infectious Diseases, and Journal of Antimicrobial Chemotherapy. He is a member of the editorial board for the publications Advances in Therapy, Clinical Investigation, Respiratory Research and Current Respiratory Medicine Reviews. Dr Sethi is a reviewer for several medical journals, including the American Journal of Respiratory and Critical Care Medicine, American Journal of Respiratory Cell and Molecular Biology, Chest, European Respiratory Journal, Infection and Immunity, JAMA, Lancet, New England Journal of Medicine, and Thorax. Dr. Sethi is currently active in several professional organizations including the American Thoracic Society and American College of Physicians. He has served as a consultant on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines for COPD, and as a member of the Department of Veterans Affairs and Department of Defense COPD Guideline Development Committee. Additionally, he is a distinguished speaker presenting papers both nationally and internationally, many with COPD as the primary focus. |
SPECIALTIES
Pulmonary & Critical Care Medicine
LICENSE AND CERTIFICATION
| Board Certification, Board Certified in Critical Care, 1995 |
| Board Certification, Board Certified in Pulmonary Disease, 1994 |
| Board Certification, Internal Medicine, 1990 |
EDUCATION
| 1984 | MBBS, Maulana Azad Medical College, Delhi, India |
PUBLICATIONS
| Murphy TF, Lesse AJ, Kirkham C, Zhong H, Sethi S, Munson RS; A Clonal Group of Nontypeable Haemophilus influenzae with Two IgA Proteases Is Adapted to Infection in Chronic Obstructive Pulmonary Disease.; PLoS One; 2011 Oct; 6(10); 25923-25923 |
| Parameswaran GI, Sethi S, Murphy TF, Parameswaran G; Effects of bacterial infection on airway antimicrobial peptides and proteins in chronic obstructive pulmonary disease.; Chest; 2011 Feb; |
| Nakamura S, Shchepetov M, Dalia AB, Clark SE, Murphy TF, Sethi S, Gilsdorf JR, Smith AL, Weiser JN; Molecular basis of increased serum resistance among pulmonary isolates of non-typeable Haemophilus influenzae.; PLoS Pathog; 2011 Jan; 7(1); 1001247-1001247 |
| Sethi S, Bartlett J., Evans R.M., Niederman M.S., Tan L..J.; Community Acquired Pneumonia.; AMA Therapeutic Insights; 2010 Sep; |
| Sethi S;Eberhardt E, Wrona C, Grove LJ, Clare R, Berenson CS; Bacterial pathogen induction of interleukin-8 (IL-8) and adherence to primary bronchial epithelial cells obtained from patients with COPD. (Abstract); ATS International Conference, New Orleans, LA; 2010 May; |
| Sethi S;Desai H, Eschberger K, Agrawal A, Grant BGB, Murphy TF; Environmental factors and daily symptoms in patients with Chronic Obstructive Pulmonary Disease. (Abstract); ATS International Conference, New Orleans, LA,; 2010 May; |
| Sethi S;Desai H, Wrona C, Murphy TF,; Mechanisms of decline in serum bactericidal activity for Nontypeable Haemophilus influenzae (NTHI) in COPD patients chronically colonized with NTHI. (Abstract); ATS International Conference, New Orleans, LA,; 2010 May; |
| Sethi S;Harvey CJ, Thimmulappa RK,Yarmus L, Feller-Kopman D, Wise R and S Biswal; Nrf2-dependent immunomodulation by sulforaphane improves bacterial phagocytosis in COPD macrophages and inhibits bacterial burden and inflammation in cigarette smoke-exposed mice. (Abstract); ATS International Conference, New Orleans, LA,; 2010 May; |
| Sethi S;Jowdy P, Desai H; Proteolysis of Sputum Immunoglobulin A (IgA) in Exacerbations of Chronic Obstructive Pulmonary Disease. Poster Discussion seesion. (Abstract); ATS International Conference, New Orleans, LA,; 2010 May; |
| Sethi S; Antibiotic resistance in Sputum Isolates of Streptococcus pneumoniae in Chronic Obstructive Pulmonary Disease is related to antibiotic exposure.; ; 2010; |
| Sethi S; Antibiotics in acute exacerbations of chronic bronchitis; . Expert Reviews on Anti- Infective Therapy.; 2010; 8(4); 405-417 |
| Jones P.W., Chen W.H., Wilcox T.K., Sethi S, Leidy; Characterizing and Quantifying the Symptomatic Features of COPD Exacerbations, for the EXACT-PRO Study Group. (In press); Chest; 2010; |
| Sethi S; Comparison of the Lung Flute with the Acapella in the Treatment of COPD with Chronic Bronchitis; ; 2010; |
| Sethi S; Development of the EXAcerbations of Chronic Obstructive Pulmonary Disease Tool (EXACT): Qualitative Methods and Content Validity.; Value in Health; 2010; |
| Sethi S ; Desai H; Exacerbations of Chronic Obstructive Pulmonary Disease; ; 2010; |
| Sethi S, McNee W.; Human models of exacerbations of COPD: No extrapolation needed. (Editorial-in press); American Journal of Respiratory and Critical Care Medicine; 2010; |
| Sethi S ;Desai H; Humoral and Pulmonary Defenses against Respiratory Infections in COPD Patients.; ; 2010; |
| Sethi S; Infection as a Comorbidity of COPD; European Respiratory Journal; 2010; 35; 1209-1215 |
| Sethi S; Molecular Diagnosis of Respiratory Tract Infection in Acute exacerbations of Chronic Obstructive Pulmonary Disease. (In press); Clinical Infectious Disease; 2010; |
| Sethi S; Pulsed Moxifloxacin for the Prevention of Exacerbations of Chronic Obstructive Pulmonary Disease: a randomized controlled trial.; Respiratory Research; 2010; |
| Sethi S; Standardizing Measurement of COPD Exacerbations:Reliability and Validity of a Patient-Reported Diary.; ; 2010; |
| Novotny LA, Adams LD, Kang DR, Wiet GJ, Cai X, Sethi S, Murphy TF, Bakaletz LO; Epitope mapping immunodominant regions of the PilA protein of nontypeable Haemophilus influenzae (NTHI) to facilitate the design of two novel chimeric vaccine candidates.; Vaccine; 2009 Aug; |
| Sethi S, Parameswaran, G.I., Murphy TF; Antimicrobial Polypeptides and Moraxella Catarrhalis in COPD. (abstract); ATS International Conference, San Diego, CA; 2009 May; |
| Sethi S;Wrona C, Grove L, Palaniyar N,CS Berenson; Antimicrobial Polypeptides in Bronchial Lavage and Bronchoalveolar Lavage: Effects of COPD and Current Smoking. Oral presentation, Mini-Symposium, Innate lung defense in chronic obstructive pulmonary disease. (Abstract); ATS International Conference, San Diego, CA,; 2009 May; |
| Sethi S;Siddiqi A, Berim I, Nabi H, Berenson CS; Association of Impaired Mucociliary Clearance with Occurrence of Exacerbations in COPD. Oral presentation, Mini-Symposium, Chronic obstructive pulmonary disease exacerbation: mechanism and management. (Abstract); . ATS International Conference, San Diego, CA; 2009 May; |
| Sethi S;Rupp A, Romberger DJ, Tang L,T.D. LeVan.; Differential Susceptibility of Nontypeable Haemophilus influenzae Strains to the Antimicrobial Peptide, Human ß-Defensin-2, in COPD Subjects. (Abstract); ATS International Conference, San Diego, CA; 2009 May; |
| Sethi S;Berenson CS, Clare RL, Maloney J,; Distinct Innate Immune Responses of COPD Alveolar Macrophages to Different Respiratory Bacterial Pathogens. Oral presentation, Mini-Symposium, Innate lung defense in chronic obstructive pulmonary disease. (Abstract); ATS International Conference, San Diego, CA,; 2009 May; |
| Sethi S;Sigua N, Rajashekhar G, Fehrenbach H, Kamocki K, Adamowicz J, Garrison J, Rush NI, Voswinckel R, Twigg III HL,Clauss M, I. Petrache.; EMAP II Is a Novel Cigarette Smoke-Induced Biomarker in Emphysema. (Abstract); ATS International Conference, San Diego, CA; 2009 May; |
| Sethi S;Leidy NK, Wilcox TK,P.W. Jones.; How Stable Is Stable in COPD? An Analysis of Day-to-Day EXACT Score Variability in Acute and Stable Patients with COPD. (Abstract); ATS International Conference, San Diego, CA,; 2009 May; |
| LaFontaine ER, Snipes LE, Bullard B, Brauer AL, Sethi S, Murphy TF; Identification of domains of the Hag/MID surface protein recognized by systemic and mucosal antibodies in adults with chronic obstructive pulmonary disease following clearance of Moraxella catarrhalis.; Clin Vaccine Immunol; 2009 May; 16(5); 653-659 |
| Sethi S;El-Dika N, Wrona C, Eschberger K and TF Murphy; Molecular Methods Detect Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis in Sputum in COPD with Much Higher Frequency Than Culture Methods. (Abstract); ATS International Conference, San Diego, CA,; 2009 May; |
| Sethi S;Jung J, Thomas MK, Sethi R ,Tewke CD, Murphy TF; New Strain Acquisition of Klebsiella Spp, Enterobacter Spp and Escherichia coli in COPD Is Not Associated with Exacerbations. (Abstract); ATS International Conference, San Diego, CA; 2009 May; |
| Sethi S;Wilcox T, Leidy NK, PW Jones; Patterns of Recovery from Exacerbations of COPD: EXACT Change Scores Days 1–14. Oral presentation, Mini-Symposium, Chronic obstructive pulmonary disease exacerbation: mechanism and management. (Abstract); ATS International Conference, San Diego, CA,; 2009 May; |
| Sethi S;Parameswaran GI,TF Murphy; Protease-Antiprotease Balance Is Altered in Colonization and Exacerbation Due to Moraxella Catarrhalis in COPD. (Abstract); ATS International Conference, San Diego, CA,; 2009 May; |
| Gaschler GJ, Skrtic M, Zavitz CC, Lindahl M, Onnervik PO, Murphy TF, Sethi S, Stämpfli MR; Bacteria challenge in smoke-exposed mice exacerbates inflammation and skews the inflammatory profile.; Am J Respir Crit Care Med; 2009 Apr; 179(8); 666-675 |
| Sethi S; . Pseudomonas aeruginosa population biology in COPD.; Journal of Infectious Diseases; 2009; 200(12); 1928-1935 |
| Sethi S; Infectious etiologies in acute exacerbations of COPD. Book chapter in Therapeutic Strategies in Acute Exacerbations of COPD.; ; 2009; |
| Sethi S; Moraxella catarrhalis acquisition, airway inflammation and protease-antiprotease balance in COPD.; BMC Infectious Diseases; 2009; |
| Sethi S; Mallia P and S Johnston; New paradigms in COPD pathogenesis II.; Proceedings of the American Thoracic Society; 2009; 6(6); 532-534 |
| Sethi S; The Use of Moraxella catarrhalis Lipooligosaccharide Mutants to Identify Specific Oligosaccharide Epitopes Recognized by Human Serum Antibodies.; Infection Immunity; 2009; 77(10); 4548-4558 |
| Sethi S, Murphy TF; Infection in the pathogenesis and course of chronic obstructive pulmonary disease.; N Engl J Med; 2008 Nov; 359(22); 2355-2365 |
| Sethi S; The problems of meta-analysis for antibiotic treatment of COPD, a heterogeneous disease: a commentary on Puhan et al.; BMC Medicine; 2008 Oct; 6(1); |
| Sethi S;Wrona C, Eschberger K, Lobbins P, TF Murphy.; Airway Inflammation and Acquisition of New Strains of Moraxella catarrhalis in COPD. (Abstract); ATS International Conference, Toronto, Canada,; 2008 May; |
| Sethi S;Wrona C, Grove L, Maloney J, C. Berenson.; Bronchial Lysozyme, Lactoferrin and SLPI Concentrations in Ex-Smokers with and without COPD. (Abstract); . ATS International Conference, Toronto, Canada; 2008 May; |
| Sethi S;Wrona C, Grove L, Maloney J, Berenson C, N. Palaniyar; Bronchoalveolar Lavage Levels of Surfactant Protein A and D Levels Are Decreased in Ex-Smokers with COPD. (Abstract); ATS International Conference, Toronto, Canada; 2008 May; |
| Sethi S;Richardson SK, Manzel LJ, Murphy TF, St. Geme III JW, DC Look; Cigarette Smoke Extract Alters Bacterial Adherence of Nontypeable Haemophilus influenzae to Airway Epithelial Cells. (Abstract); .ATS International Conference, Toronto, Canada,; 2008 May; |
| Sethi S;Siddiqi A, Grove L, Lobbins P, Eschberger K, Murphy TF,; Comparison of Antibiotic Susceptibility of Pseudomonas aeruginosa Strains Isolated from Sputum in COPD with Nosocomial Strains. (abstract); ATS International Conference, Toronto, Canada; 2008 May; |
| Sethi S;Jones PW, Chen WH, Leidy NK, Petrillo JM,; Creating a Unidimensional Measure of Overall Exacerbation Severity: The Exacerbations of Chronic Pulmonary Disease Tool (EXACT). (Abstract); ATS International Conference, Toronto, Canada,; 2008 May; |
| Sethi S and the PULSE study group; Determinants of Exacerbation Frequency in the PULSE Study. (Abstract); ATS International Conference, Toronto, Canada,; 2008 May; |
| Sethi S; Development of a Patient-Reported Outcome (PRO) Measure in AECOPD. (Abstract); ATS International Conference, Toronto, Canada,; 2008 May; |
| Sethi S;Wilcox TK, Leidy NK, Chen WH,Jones PW.; Does a Measurement Tool of COPD Exacerbation Have a Single Measurement Scale with Multiple Domains? Exploratory and Confirmatory Factor Analysis of the Exacerbations of Chronic Pulmonary Disease Tool (EXACT). (Abstract); ATS International Conference, Toronto, Canada,; 2008 May; |
| Sethi S;Lucht LA, Kristoff J, Norris KA,Sciurba FC, Wei K, Tseng W, A. Morris.; Pneumocystis Antibody Response and Colonization in COPD. (Abstract); ATS International Conference, Toronto, Canada; 2008 May; |
| Sethi S and the PULSE study group; Reduction in Number of Acute Exacerbations of COPD with Moxifloxacin in Patients with Mucopurulent/Purulent Sputum: A PULSE Study Sub-Analysis. Oral presentation. (Abstract); ATS International Conference, Toronto, Canada; 2008 May; |
| Sethi S;Leidy NK, Wilcox TK, Burke LB, Howard KA, Petrillo JM, Jones PW,Powers JH.; Reliability and Validity of the Exacerbations of Chronic Pulmonary Disease Tool (EXACT): A New Outcome Measure for Evaluating Exacerbations in COPD. (Abstract); ATS International Conference, Toronto, Canada,; 2008 May; |
| Sethi S; Siddiqi A, Wrona C, Eschberger K, Murphy TF,; Serum C-Reactive Protein (CRP) in COPD and Its Relationship to Inhaled and Systemic Corticosteroid Use. (Abstract); ATS International Conference, Toronto, Canada; 2008 May; |
| Sethi S; Antibiotics. Book Chapter in Asthma and COPD, 2nd Edition; ; 2008; |
| Sethi S; Bacterial infection, book chapter in Chronic Obstructive Lung Diseases 2nd Edition.; Chronic Obstructive Lung Diseases; 2008; |
| Sethi S,Decramer M, Rennard S, Troosters T, Mapel DW, Giardino N, Mannino D, Wouters E, and CB Cooper; COPD as a Lung Disease With Systemic Consequences – Clinical Impact, Mechanisms, and Potential for Early Intervention.; COPD: Journal of Chronic Obstructive Pulmonary Disease 5; 2008; 5(4); 235-256 |
| Sethi S,Bartlett J; Diagnosis and treatment of infection in acute exacerbations of chronic obstructive pulmonary disease; UpToDate; 2008; |
| Sethi S;Desai H.; Do airway bacteria cause COPD exacerbations? Book Chapter in Acute Exacerbations of COPD.; ; 2008; |
| Sethi S; Optimizing antibiotic therapy for acute exacerbations of COPD.; International Journal of COPD; 2008; 3(1); 31-34 |
| Murphy TF, Brauer AL, Eschberger K, Lobbins P, Grove L, Cai X, Sethi S; Pseudomonas aeruginosa in Chronic Obstructive Pulmonary Disease.; Am J Respir Crit Care Med; 2008 Jan; |
| Sethi S; Serial isolates of persistent Haemophilus influenzae in patients with chronic obstructive pulmonary disease express diminishing quntities of the HMW1 and HMW2 adhesins; Infection Immunity; 2008; 76(10); |
| Sethi S; Treating and preventing Infections, book chapter in Clinical Management of Chronic Obstructive Pulmonary Disease.; Clinical management of chronic obstructive pulmonary disease; 2008; |
| Sethi S, Wrona C, Eschberger K, Lobbins P, Cai X, Murphy TF; Inflammatory Profile of New Bacterial Strain Exacerbations of Chronic Obstructive Pulmonary Disease.; Am J Respir Crit Care Med; 2007 Dec; |
| Sethi S, File T., Dagan R.; Acute exacerbations of chronic bronchitis: diagnosis and therapy.; Journal of Respiratory Diseases; 2007 Oct; |
| Anzueto A, Sethi S, Martinez FJ; Exacerbations of chronic obstructive pulmonary disease.; Proc Am Thorac Soc; 2007 Oct; 4(7); 554-564 |
| Sethi S; Clinical and safety results of the PULSE Study. Oral presentation. (Abstract); ERS Annual Congress, Stockholm, Sweden,; 2007 Sep; |
| Sethi S;Kruesmann F, Haverstock D, Perroncel R, Choudhri SH.; Correlation between eradication of infecting organism on days 3 to 5 of antibiotic therapy and clinical cure in patients with acute exacerbations of chronic bronchitis (AECB). (Abstract); ERS Annual Congress, Stockholm, Sweden; 2007 Sep; |
| Sethi S;Gaillat J, Garau J,Anzueto A, Guillemot D, Weber P.; Impact of telithromycin, azithromycin and cefuroxime axetil on the carriage of resistant Streptococcus pneumoniae in patients with acute exacerbation of chronic bronchitis. (Abstract); ERS Annual Congress, Stockholm, Sweden,; 2007 Sep; |
| Sethi S;Van Parijs BA,Lode H, Wilson R, Bhatt K, Fernandes A, Berkowitz E, Chang C, Nicholson T, Li G, Jones PW; Patient-Reported Outcome (PRO) Measure in AECOPD. (Abstract); ICAAC, Chicago, IL,; 2007 Sep; |
| Malley R, Lipsitch M, Bogaert D, Thompson CM, Hermans P, Watkins AC, Sethi S, Murphy TF; Serum antipneumococcal antibodies and pneumococcal colonization in adults with chronic obstructive pulmonary disease.; J Infect Dis; 2007 Sep; 196(6); 928-935 |
| Sethi S, Sethi R, Eschberger K, Lobbins P, Cai X, Grant BJ, Murphy TF; Airway bacterial concentrations and exacerbations of chronic obstructive pulmonary disease.; Am J Respir Crit Care Med; 2007 Aug; 176(4); 356-361 |
| Sethi S;Richardson SK, Cholon DM, Chin CL, Murphy TF, Sethi S, St. Geme III JW, Look DC.; Altered Adhesin Expression on Persistent Haemophilus influenzae Strains from Patients with Chronic Obstructive Pulmonary Disease. (Abstract); ATS International Conference, San Francisco, CA,; 2007 May; |
| Sethi S;Clare RL, Grove L, Maloney J, Berenson CS; Complement Mediation of Human Alveolar Macrophage Phagocytosis Is Distinct for Different Respiratory Pathogens. (Abstract); ATS International Conference, San Francisco, CA,; 2007 May; |
| Sethi S;Leidy NK, Howard K, Petrillo J, Wilcox T,Jones PW,; EXACT-PRO Study Group. The EXAcerbation of Chronic Pulmonary Disease Tool [EXACT]: A Patient-Reported Outcome. (Abstract); ATS International Conference, San Francisco, CA,; 2007 May; |
| Sethi S;Wrona C, Murphy TF.; Identification of Nontypeable Haemophilus influenzae (NTHI) Antigens for Human Bactericidal Antibodies That Develop Following Acute Exacerbations of COPD. (Abstract); ATS International Conference, San Francisco, CA; 2007 May; |
| Sethi S; Intermittent Pulse Therapy of Moxifloxacin To Prevent Acute Exacerbations in COPD Patients with Chronic Bronchitis: Demographics and Baseline Bacteriology. (Abstract); ATS International Conference, San Francisco, CA; 2007 May; |
| Sethi S;El-Dika N, T.F. Murphy TF, Wrona C, Eschberger K,; PCR Detection of Streptococcus pneumoniae and Moraxella catarrhalis in Sputum in the Stable Phase and during Exacerbations of COPD. (Abstract); ATS International Conference, San Francisco, CA; 2007 May; |
| Sethi S;Veeramachaneni S, Murphy TF, Wrona C, Eschberger K; Serum IgG and Sputum IgA Antibody Levels to Nontypeable Haemophilus influenzae Are Markers of Recurrent Infection in COPD. (Abstract); ATS International Conference, San Francisco, CA; 2007 May; |
| Sethi S;Wrona C, Cai X,Eschberger K, Murphy TF; Stability of Serum C-Reactive Protein (CRP) in COPD and Its Relationship to Exacerbation Frequency and Mortality. (Abstract); ATS International Conference, San Francisco, CA; 2007 May; |
| Sethi S; An epidemiological analysis of Streptococcus pneumoniae infection in outpatient acute exacerbations of chronic bronchitis (AECB). (Abstract); ECCMID/ICC, Munich, Germany,; 2007 Apr; |
| Sethi S, Blasi F.; Antibiotics allergy in a COPD patient with frequent bacterial exacerbations. Book Chapter in Clinical Challenges in COPD.; Clinical Challenges in COPD; 2007; |
| Sethi S; Bacteria, Book chapter in Chronic Obstructive Pulmonary Disease.; Chronic Obstructive Pulmonary Disease; 2007; |
| Sethi S; Bronchoscopic Valor in Exacerbations of Chronic Bronchitis A Tale of Bugs and Drugs. (Editorial); Journal of Bronchology; 2007; 14(3); 137-139 |
| Murphy TF, Brauer AL, Sethi S, Kilian M, Cai X, Lesse AJ; Haemophilus haemolyticus: a human respiratory tract commensal to be distinguished from Haemophilus influenzae.; J Infect Dis; 2007 Jan; 195(1); 81-89 |
| Sethi S;Murphy TF, Cai X, Richter SS, Doern GV; Antibiotic exposure in COPD and the development of penicillin and erythromycin resistance in Streptococcus pneumonia. (Abstract); ICAAC, San Francisco, CA,; 2006 Sep; |
| Sethi S;Anzueto A, Wilson R, Jones PW, Wedzicha JA, Miravitlles M, Kureshi A, Sagnier P, Russell J, Schmitt M, Arvis P, Hampel B.; Placebo-controlled, double-blind trial of chronic, intermittent ‘pulse‘ therapy of moxifloxacin to prevent acute exacerbations in COPD patients with chronic bronchitis: baseline data. (Abstract); ERS Annual Congress, Munich, Germany; 2006 Sep; |
| Fernaays MM, Lesse AJ, Sethi S, Cai X, Murphy TF; Differential genome contents of nontypeable Haemophilus influenzae strains from adults with chronic obstructive pulmonary disease.; Infect Immun; 2006 Jun; 74(6); 3366-3374 |
| Sethi S;Wrona C, Veeramachaneni S, Eschberger K, Murphy TF; Changes in serum c-reactive protein (CRP) with onset and resolution of exacerbations of COPD and relationship to etiology. (Abstract); ATS International Conference, San Diego, CA,; 2006 May; |
| Sethi S;Wei KK,Tseng W, Morris A.; Detection of Pneumocystis in subjects with COPD exacerbations. (Abstract); ATS International Conference, San Diego, CA,; 2006 May; |
| Sethi S;Brauer AL, Lesse AJ,Kilian M, Cai X, Murphy TF; Haemophilus haemolyticus: a human respiratory tract commensal to be distinguished from Haemophilus influenzae. (Abstract); American Society for Microbiology 106th General Meeting. Orlando, FL,; 2006 May; |
| Sethi S;Veeramachaneni S, Wrona C, Murphy TF,; Lack of host immune and inflammatory response to gram-negative bacilli in exacerbations of COPD. (Abstract); ATS International Conference, San Diego, CA; 2006 May; |
| Sethi S;Grove L, Wrona C, Maloney J.; Prevalence of bacterial colonization in COPD is not altered by fluticasone/salmeterol. (Abstract); ATS International Conference, San Diego, CA,; 2006 May; |
| Sethi S;ElDika N, Eschberger K, Lobbins P, Murphy TF,; Relationship of Pseudomonas aeruginosa isolation to lung function, hospitalization and mortality in COPD. (Abstract); ATS International Conference, San Diego, CA,; 2006 May; |
| Niederman M.S., Anzueto A., Sethi S, Choudhri S., Kureishi A., Haverstock D., Perroncel R.; Eradication of H. influenzae in AECB: A pooled analysis of moxifloxacin phase III trials compared with macrolide agents.; Respiratory Medicine; 2006 Mar; 174(1); 31-40 |
| Berenson CS, Maloney J., Grove L., Wrona C., Sethi S; Impaired Alveolar Macrophage Response to Haemophilus Antigens in Chronic Obstructive Lung Disease.; Journal of Respiratory and Critical Care Medicine; 2006 Mar; 174(1); 31-40 |
| Sethi S, Maloney J., Grove L., Wronta C.T., Berenson CS; Airway inflammation and bronchial bacterial colonization in ex-smokers with COPD.; American Journal of Respiratory and Critical Care Medicine; 2006; 173(9); 991-998 |
| Sethi S; Co-infection in exacerbations of COPD: A new frontier. (editorial); Chest; 2006; 129(2); 223-224 |
| Adlowitz D., Kirkham, C., Sethi S, Murphy TF; Human Serum and Mucosal Antibody Responses to Outer Membrane Protein G1b of Moraxella catarrhalis in Chronic Obstructive Pulmonary Disease.; FEMS Immunology; 2006; 46(1); 139-146 |
| Berenson CS, Garlipp M.A., Grove L.L., Maloney J., Sethi S; Impaired phagocytosis of nontypeable Haemophilus influenzae by human alveolar macrophages in chronic obstructive pulmonary disease.; Journal of Infectious Disease; 2006; 194(10); 1375-1384 |
| Look D.C., Chin C.L., Manzel L.J., Lehman E.E., Humlicek A.L., Shi L., Starner T.D., Denning G.M., Murphy TF, Sethi S; Modulation of airway inflammation by Haemophilus influenzae isolates associated with chronic obstructive pulmonary disease exacerbation.; Proceedings of the American Thoracic Society; 2006; 3(6); 482-483 |
| Veeramachaneni S., Sethi S; Pathogenesis of bacterial exacerbations of COPD.; COPD: Journal of Chronic Obstructive Pulmonary Disease; 2006; 3(2); 109-1116 |
| Eldika, N., Sethi S; Role of Nontypeable Haemophilus influenzae in exacerbations and progression of COPD.; Current Opinion in Pulmonary Medicine; 2006; 12(2); 118-124 |
| Murphy TF, Brauer A., Grant BJ, Sethi S; Moraxella catarrhalis in chronic obstructive pulmonary disease: burden of disease, dynamics of carriage and immune responses; American Journal of Respiratory and Critical Care Medicine; 2005 Jul; 172(2); 195-199 |
| Sethi S; Moxifloxacin for the treatment of acute exacerbations of chronic obstructive pulmonary disease.; Clinical Infectious Diseases; 2005 Jul; 15(41); S177-S185 |
| Sethi S;Johnson A, Kazani S, Hiltke TJ,. Musher DM, Ceasar H, Hollingshead SK, Coan PA, Briles DE, Morona J, Paton JC,Murphy TF.; Antibody Response to Capsular and Noncapsular Antigens of Streptococcus pneumoniae in Chronic Obstructive Pulmonary Disease. (Abstract); American Society of Microbiology Annual Meeting, Atlanta, GA,; 2005 Jun; |
| Sethi S;Fernaays MM, Lesse AJ, Murphy TF; Genes Associated with Virulence of Nontypeable Haemophilus influenzae in Chronic Obstructive Pulmonary Disease. (Abstract); American Society of Microbiology Annual Meeting, Atlanta, GA,; 2005 Jun; |
| Sethi S;; Identification of Surface Antigens of Moraxella catarrhalis as Targets of Human Serum Antibody Responses in Chronic Obstructive Pulmonary Disease. (Abstract); .American Society of Microbiology Annual Meeting, Atlanta, GA; 2005 Jun; |
| Sethi S;Delgado EM, Eschberger K, Lobbins P, Murphy TF; Acquisition of New Bacterial Strains in COPD Is Independent of Systemic Antibiotic and Corticosteroid Use. (Abstract); ATS International Conference, San Diego, CA,; 2005 May; |
| Sethi S;Brown S, Patel M.; Antibacterial Activity of Telithromycin and Comparators Against Pathogens Isolated from Patients with Acute Exacerbations of Chronic Bronchitis in PROTEKT (1999–2003). (Abstract); ATS International Conference, San Diego, CA; 2005 May; |
| Sethi S;Wrona C, Maloney J, Berenson C; Bacterial Colonization Is Associated with Increased Matrix Metalloproteinase-9 (MMP-9) in Bronchoalveolar Lavage of Ex-Smokers with Stable COPD. (Abstract); ATS International Conference, San Diego, CA,; 2005 May; |
| Sethi S;Wrona C Eschberger K, Lobbins P, Murphy TF; Changes in Airway Inflammation with Onset and Resolution of Exacerbations of COPD. (Abstract); ATS International Conference, San Diego, CA; 2005 May; |
| Sethi S;Brauer A Lesse AJ, Doern GV, Murphy TF; Distinct Clinical Characteristics of Variant Strains of Nontypeable Haemophilus influenzae (NTHI) Isolated from Patients with COPD. (Abstract); .ATS International Conference, San Diego, CA; 2005 May; |
| Sethi S;Maloney J, Grove L, Wrona C, Berenson C.; Inflammatory Cytokine Response of Alveolar Macrophages to Outer Membrane Components of Nontypeable Haemophilus influenzae (NTHI) Is Diminished in COPD. (Abstract); ATS International Conference, San Diego, CA; 2005 May; |
| Sethi S;Garlipp MA, Maloney J, Berenson C.; Phagocytosis of Nontypeable Haemophilus influenzae (NTHI) by Alveolar Macrophages Is Diminished in COPD. (Abstract); ATS International Conference, San Diego, CA,; 2005 May; |
| Sethi S;Morris A, Sciurba FC, Tseng W, Norris KA,; Relationship of Pneumocystis Colonization and COPD. (Abstract); ATS International Conference, San Diego, CA; 2005 May; |
| Sethi S;Eschberger K, Lobbins P, Sethi R, Agarwal S, Grant BJB, Murphy TF; Sputum Bacterial Titers and Acute Exacerbations of COPD. (Abstract); ATS International Conference, San Diego, CA; 2005 May; |
| Murphy TF, Kirkham C, Sethi S, Lesse AJ; Expression of a peroxiredoxin-glutaredoxin by Haemophilus influenzae in biofilms and during human respiratory tract infection.; FEMS Immunol Med Microbiol; 2005 Apr; 44(1); 81-89 |
| Sethi S, Anzueto A, Farrell D.J.; Antibiotic activity of telithromycin and comparators against bacterial pathogens isolated from 3,043 patients with acute exacerbation of chronic bronchitis.; Annals of Clinical Microbiology and Antimicrobials; 2005 Mar; 4(1); 5-5 |
| Murphy TF, Brauer, A.L., Adler, B., Sethi S; Antigenic specificity of the mucosal antibody response to Moraxella catarrhalis in chronic obstructive pulmonary disease.; Infection and Immunity; 2005; 73(12); 8161-8166 |
| Chin C.L., Manzel L.J., Lehman E.E., Humlicek, A.L., Shi L., Starner T.D., Denning G.M., Murphy TF, Sethi S, Look D.C.; Haemophilus influenzae from patients with COPD exacerbation induce more inflammation than colonizers.; American Journal of Respiratory and Critical Care Medicine; 2005; 172; 85-91 |
| Adlowitz D., Sethi S, Adler B., Cullen, P., Murphy TF; Human Antibody Response to Outer Membrane Protein G1a, a Lipoprotein of Moraxella catarrhalis.; Infection and Immunity; 2005; 73(10); 6601-6607 |
| Murphy TF, Brauer A.L., Aebi C., Sethi S; Identification of surface antigens of Moraxella catarrhalis as targets of human serum antibody responses in chronic obstructive pulmonary disease.; Infection and Immunity; 2005; 73(6); 3471-3478 |
| Berenson CS, Murphy TF, Wrona, C.T., Sethi S; Outer membrane protein P6 of nontypeable Haemophilus influenzae is a potent and selective inducer of human macrophage cytokines; Infection and Immunity; 2005; 73(5); 2728-2735 |
| Sethi S; Pathogenesis and treatment of acute exacerbations of COPD.; Seminars in Respiratory and Critical Care Medicine; 2005; 26(2); 192-203 |
| Sethi S; TF Murphy.; RSV infection: not for kids only. (editorial); New England Journal of Medicine; 2005; 352(17); 1810-1812 |
| Sethi S, Breton J., Wynne B.; The efficacy and safety of pharmacokinetically enhanced amoxicillin/clavulanate, 2000/125mg twice daily for 5 days, versus amoxicillin/clavulanate, 875/125mg twice daily for 7 days in the treatment of acute exacerbations of chronic bronchitis; Antimicrobial Agents and Chemotherapy; 2005; 49(1); 153-160 |
| Sethi S, Murphy TF; Acute exacerbations of chronic bronchitis: new developments concerning microbiology and pathophysiology--impact on approaches to risk stratification and therapy.; Infect Dis Clin North Am; 2004 Dec; 18(4); 861-882 |
| Sethi S; Musculoskeletal effects of chronic obstructive pulmonary disease: prevalent,linked, but ignored. (comment); Am J Respir Crit Care Med; 2004 Dec; 170(12); 1267-1268 |
| Sethi S, File TM; Managing patients with recurrent acute exacerbations of chronic bronchitis: a common clinical problem.; Curr Med Res Opin; 2004 Oct; 20(10); 1511-1521 |
| Sethi S, Fogarty C, Fulambarker A; A randomized, double-blind study comparing 5 days oral gemifloxacin with 7days oral levofloxacin in patients with acute exacerbation of chronic bronchitis.; Respir Med; 2004 Aug; 98(8); 697-707 |
| Murphy TF, Brauer AL, Schiffmacher AT, Sethi S; Persistent colonization by Haemophilus influenzae in chronic obstructive pulmonary disease.; Am J Respir Crit Care Med; 2004 Aug; 170(3); 266-272 |
| Sethi S;Maloney J, Grove L, Wrona C, Berenson CS.; Bacterial ‘Colonization’ of the Lower Respiratory Tract Is Associated with Airway Inflammation in Ex-Smokers with Stable COPD. (Abstract); ATS International Conference, Orlando, FL,; 2004 May; |
| Sethi S;Grove L, Murphy TF,; Epithelial cell invasion and phosphorylcholine expression among complement sensitive and resistant strains of Haemophilus influenzae isolated from patients with exacerbations of COPD. (Abstract); American Society of Microbiology Annual Meeting, New Orleans, LA; 2004 May; |
| Sethi S;Johnson AJ, Kazani S, Hiltke T, Sethi S, Ceaser H, Musher D, Murphy TF; Human antibody response to Streptococcus pneumoniae in chronic obstructive pulmonary disease. (Abstract); American Society of Microbiology Annual Meeting, New Orleans, LA; 2004 May; |
| Sethi S;Berenson C, Wrona C, Grove L, Maloney J; Nontypeable Haemophilus influenzae antigen regulation of human macrophage inflammation. (Abstract); American Society of Microbiology Annual Meeting, New Orleans, LA,; 2004 May; |
| Sethi S;Garlipp M, Sethi S, Grove L, Maloney J, Berenson C.; Phagocytosis and intracellular survival of Nontypeable Haemophilus influenzae in human alveolar macrophages in chronic obstructive pulmonary disease. (Abstract); American Society of Microbiology Annual Meeting, New Orleans, LA,; 2004 May; |
| Sethi S; Serum immune response to ‘colonization’ by Haemophilus influenzae in COPD. (Abstract); American Society of Microbiology Annual Meeting, New Orleans, LA; 2004 May; |
| Sethi S; Serum immune response to ‘colonization’ by Haemophilus influenzae in COPD. (Abstract); ATS International Conference, Orlando, FL,; 2004 May; D84; |
| Sethi S;Brauer A, Lobbins P, Eschberger K, Murpy TF; Systemic and mucosal immune response to Moraxella catarrhalis in COPD. (Abstract); ATS International Conference, Orlando, FL; 2004 May; A84; |
| Sethi S; New developments in the pathogenesis of acute exacerbations of chronic obstructive pulmonary disease.; Curr Opin Infect Dis; 2004 Apr; 17(2); 113-119 |
| Sethi S, Wrona C, Grant BJ, Murphy TF; Strain-specific immune response to Haemophilus influenzae in chronic obstructive pulmonary disease.; Am J Respir Crit Care Med; 2004 Feb; 169(4); 448-453 |
| Sethi S; Bacteria in exacerbations of COPD: Phenomenon or epiphenomenon; Proceedings of the American Thoracic Society; 2004; 1; 109-114 |
| Sethi S; Gatifloxacin in community-acquired respiratory tract infection.; Expert Opin Pharmacother; 2003 Oct; 4(10); 1847-1855 |
| Sethi S;Maloney J, Grove L, Smigiera J, Berenson C.; Colonization’ of the lower respiratory tract and airway neutrophilia in ex-smokers with stable COPD. (Abstract); ATS International Conference, Seattle, WA; 2003 May; A32; H63 |
| Sethi S;Maloney J, Grove L, Wrona C, Hawkins S.; Comparison of the safety and efficacy of sputum induction with the lung flute and with hypertonic saline in COPD. (Abstract); ATS International Conference, Seattle, WA,; 2003 May; B49; D82 |
| Sethi S;Brauer AL, Sethi S, Murphy TF.; New serum IgG and sputum IgA to Moraxella catarrhalis following exacerbations and asymptomatic colonization of adults with chronic obstructive pulmonary disease. (Abstract); American Society of Microbiology Annual Meeting, Washington, DC,; 2003 May; |
| Sethi S;Berenson C, Smigiera J, Grove L, Wrona C,; Nontypeable Haemophilus influenzae antigen regulation of human macrophage inflammation. (Abstract); American Society of Microbiology Annual Meeting, Washington, DC,; 2003 May; |
| Sethi S;, Maloney J, Grove L, Wrona C, Hawkins S; Safety and efficacy of sputum induction with the lung flute in healthy subjects. (Abstract); ATS International Conference, Seattle, WA,; 2003 May; B49; D81 |
| Sethi S;Veeramachaneni S, Murphy TF; Serum immune response to Pseudomonas aeruginosa, other gram-negative bacilli and Haemophilus parainfluenzae in acute exacerbations of COPD. (Abstract); ATS International Conference, Seattle, WA,; 2003 May; D92; 221 |
| Sethi S; Strain specific immune response to Haemophilus influenzae in exacerbations of COPD. (Abstract); . American Society of Microbiology Annual Meeting, Washington, DC,; 2003 May; |
| Sethi S;Wrona C, Braciak C, Freeburg R, Evans N, Murphy TF; Strain specific immune response to Haemophilus influenzae in exacerbations of COPD. (Abstract); ATS International Conference, Seattle, WA; 2003 May; A16; |
| Sethi S, Dagan, R.; Acute exacerbations of chronic bronchitis: Diagnosis and therapy; Respiratory Diseases; 2003; 24(6); 257-263 |
| MURPHY TF; Horizontal transfer of the gene encoding outer membrane protein P2 of nontypeable Haemophilus influenzae in a patient with chronic obstructive pulmonary disease.; Journal of Infectious Diseases; 2003 Jan; 188; 114-117 |
| MURPHY TF; Human immune response to outer membrane protein CD of Moraxella catarrhalis in adults with chronic obstructive pulmonary disease.; Infection and Immunity; 2003; 71; 1288-1294 |
| Sethi S; The role of antibiotics in acute exacerbations of chronic obstructive pulmonary disease; Current Infectious Disease Reports; 2003; 5; 9-15 |
| Sethi S;Evans N, Murphy TF; Acquisition of a new bacterial strain and occurrence of exacerbation of COPD. (Abstract); ATS International Conference, Atlanta, GA,; 2002 May; B28; A269 |
| Sethi S;Ahn JH, Wrona C,; Exacerbation and transient colonization strains of nontypeable Haemophilus influenzae differ in invasion and pro-inflammatory cytokine induction of H292 cells. (Abstract); ATS International Conference, Atlanta, GA; 2002 May; B37; A57 |
| Sethi S;Hiltke TJ, Schiffmacher AT, Murphy TF.; Horizontal transfer of the gene encoding outer membrane protein 2 in a patient with chronic obstructive pulmonary disease. (Abstract); American Society of Microbiology Annual Meeting, Salt Lake City UT,; 2002 May; |
| Sethi S;Obaji A, Murphy TF,; Relationship of sputum elastase to clinical and bacteriological states in COPD. (Abstract); ATS International Conference, Atlanta, GA,; 2002 May; B28; A326 |
| Sethi S;Brauer AL, Murphy TF.; Strain specificity and duration of human immune response to Moraxella catarrhalis. (Abstract); American Society of Microbiology Annual Meeting, Salt Lake City UT; 2002 May; |
| Niederman MS, Sethi S, Martinez F; Acute exacerbations of chronic obstructive pulmonary disease. (letter); Ann Intern Med; 2002 Apr; 136(7); 556-558 |
| Abe Y, Murphy TF, Sethi S, Faden HS, Dmochowski J, Harabuchi Y, Thanavala YM; Lymphocyte proliferative response to P6 of Haemophilus influenzae is associatedwith relative protection from exacerbations of chronic obstructive pulmonary disease.; Am J Respir Crit Care Med; 2002 Apr; 165(7); 967-971 |
| Sethi S; Bacterial pneumonia. Managing a deadly complication of influenza in older adults with comorbid disease.; Geriatrics; 2002 Mar; 57(3); 56-61 |
| Hiltke TJ, Sethi S, Murphy TF; Sequence stability of the gene encoding outer membrane protein P2 of nontypeableHaemophilus influenzae in the human respiratory tract.; J Infect Dis; 2002 Mar; 185(5); 627-631 |
| Bakri F, Brauer AL, Sethi S, Murphy TF; Systemic and mucosal antibody response to Moraxella catarrhalis after exacerbationsof chronic obstructive pulmonary disease.; J Infect Dis; 2002 Mar; 185(5); 632-640 |
| Sethi S; Acute exacerbations of COPD: A "multi-pronged" approach; Respiratory Diseases; 2002; 23; 217-225 |
| Murphy TF, Sethi S; Chronic obstructive pulmonary disease: Role of bacteria and guide to antibacterial selection in the older patient; Drugs and Aging; 2002; 19; 761-775 |
| Sethi S; Efficacy of antibiotics in acute exacerbations: A review of the literature; Consultant; 2002; 42; S13-S19 |
| Murphy TF, Sethi S, Hill SL, Stockley RA; Inflammatory markers in bacterial exacerbations of COPD. (letter); Am J Respir Crit Care Med; 2002 Jan; 165(1); 132-132 |
| Sethi S, Evans N, Grant BJ, Murphy TF; New strains of bacteria and exacerbations of chronic obstructive pulmonary disease.; New England Journal of Medicine; 2002; 347(7); 465-471 |
| Sethi S;Walters A, Veeramachaneni S, Murphy TF.; Characterization of bactericidal antibodies to tbp2 (OMP B1) of M. catarrhalis. (Abstract); American Society of Microbiology Annual Meeting, Orlando Fl,; 2001 May; B337; 125 |
| Sethi S;Evans N, Wrona C, Walters A, Murphy TF; Human immune response to ‘colonization’ by Haemophilus influenzae in stable COPD. (Abstract); ATS International Conference, San Francisco, CA,; 2001 May; B30; J125 |
| Sethi S;Veeramachaneni S, Evans N, Wrona C, Walters A, Murphy TF; Human immune response to Haemophilus spp. in acute exacerbations of COPD. (Abstract); ATS International Conference, San Francisco, CA,; 2001 May; C92; 331 |
| Sethi S;Bakri FG, Murphy TF; Human immune response to Moraxella catarrhalis following exacerbations of chronic obstructive pulmonary disease. (Abstract); American Society of Microbiology Annual Meeting, Orlando Fl,; 2001 May; E7; 330 |
| Sethi S;Obaji A, Murphy TF; Lung function decline in advanced COPD. (Abstract); ATS International Conference, San Francisco, CA; 2001 May; C52; K9 |
| Sethi S;Hiltke TJ, Murphy TF.; Sequence stability of the gene encoding outer membrane protein P2 of nontypeable Haemophilus influenzae in the human respiratory tract. (Abstract); American Society of Microbiology Annual Meeting, Orlando Fl,; 2001 May; B246; 96 |
| Sethi S, Murphy TF; Bacterial infection in chronic obstructive pulmonary disease in 2000: a state-of-the-art review.; Clin Microbiol Rev; 2001 Apr; 14(2); 336-363 |
| Obaji, A., & Sethi S.; Acute exacerbations of chronic bronchitis: What role the new fluoroquinolones?; Drugs and Aging; 2001 Jan; 18; 1-11 |
| Sethi S.; Antibiotics and acute exacerbation of COPD; Advance for Managers of Respiratory Care; 2001 Jan; 10(8); 28-31 |
| Sethi,S./author of chapter Editors: Voelkel, N.F. & MacNee, W. Publisher: B.C. Decker, Inc.; Bacterial Infection, book chapter in Chronic Obstructive Lung Diseases.; Book Chapter in Chronic Obstructive Lung Disease; 2001; |
| Fendrick, A.M., Saint, S., Brook, I., Jacobs, M.R., Pelton, S., Sethi S; Diagnosis and treatment of upper repiratory tract infections in the primary care setting; Clinical Therapeutics; 2001 Jan; 23; 1683-1706 |
| Sheikh, S., & Sethi S.; Management of infectious excerbation of COPD; Home Health Care Consultant; 2001 Jan; 8; 21-27 |
| Sethi S, Muscarella K, Evans N, Klingman KL, Grant BJ, Murphy TF; Airway inflammation and etiology of acute exacerbations of chronic bronchitis.; Chest; 2000 Dec; 118(6); 1557-1565 |
| Sethi S; Pericolo di infiammazione. Le infezioni broncopolmonari; Ricera Roche (Italian); 2000 Dec; |
| Murphy TF, Sethi S, Niederman MS; The role of bacteria in exacerbations of COPD. A constructive view.; Chest; 2000 Jul; 118(1); 204-209 |
| Sethi S;Evans N, Wrona C, Murphy TF; Airway inflammation in COPD: effects of clinical status and bacterial infection. (Abstract); ALA/ATS International Conference, Toronto, Ontario,; 2000 May; D32; C25 |
| Sethi S;Veeramachaneni S, Evans N, Wrona C, Grant BJB.; Airway inflammation in stable COPD: effect of bacterial colonization is independent of smoking and severity of airway obstruction. (Abstract); ALA/ATS International Conference, Toronto, Ontario, May 2000.; 2000 May; D32; C26 |
| Sethi S; Bacterial infection and the pathogenesis of COPD.; Chest; 2000 May; 117(5 Sup); 286-291 |
| Sethi S;Wrona C, Murphy TF.; Characterization of adherence of Moraxella catarrhalis to Hep-2 cells. (Abstract); American Society of Microbiology Annual Meeting, Los Angeles CA; 2000 May; B121; 68 |
| Sethi S; Infectious etiology of acute exacerbations of chronic bronchitis.; Chest; 2000 May; 117(5 Sup); 380-385 |
| Sethi S., Muscarella, K.A., Evans, N., Klingman, K.L., & Murphy, T.F.; Acute bacterial exacerbations of COPD are associated with greater airway inflammation than non-bacterial exacerbations; Chest; 2000 Jan; 118; 1557-1565 |
| Sethi S; TF Murphy; Chronic obstructive pulmonary disease. (letter); New England Journal of Medicine; 2000; 343; 1969-1970 |
| Murphy TF, Kirkham C, DeNardin E, Sethi S; Analysis of antigenic structure and human immune response to outer membraneprotein CD of Moraxella catarrhalis.; Infect Immun; 1999 Sep; 67(9); 4578-4585 |
| Murphy TF, Sethi S, Klingman KL, Brueggemann AB, Doern GV; Simultaneous respiratory tract colonization by multiple strains of nontypeablehaemophilus influenzae in chronic obstructive pulmonary disease: implications for antibiotic therapy.; J Infect Dis; 1999 Aug; 180(2); 404-409 |
| Sethi S;Muscarella K, Evans N, Klingman KL, Grant BJB, Murphy TF.; Comparison of airway inflammation in acute bacterial and non-bacterial exacerbations of COPD. (Abstract); ALA/ATS International Conference, San Diego CA; 1999 May; D31; 158 |
| Sethi S;Yuskiw N, Klingman KL, Brueggemann AB, Doern GV, Murphy TF; Simultaneous respiratory tract colonization by multiple strains of nontypeable Haemophilus influenzae in chronic obstructive pulmonary disease: implications for antibiotic therapy. (Abstract); American Society of Microbiology Annual Meeting, Chicago IL,; 1999 May; A57; 12 |
| Sethi S;Paluri R, Murphy TF; Sputum bacterial titers do not increase during acute exacerbations of chronic obstructive pulmonary disease (COPD).; American Society of Microbiology Annual Meeting, Chicago IL,; 1999 May; D/B(289); 264 |
| Sethi S;Muscarella K, Evans N, Klingman KL, Grant BJB, Murphy TF; Bacterial colonization enhances airway inflammation. (Abstract); ALA/ATS International Conference, San Diego CA; 1999 Apr; D31; A142 |
| Sethi S;Paluri R, Grant BJB, Murphy TF; Prediction models for the etiology of acute exacerbations of COPD. (Abstract); ALA/ATS International Conference, San Diego ,CA; 1999 Apr; D31; A141 |
| Sethi S; Infectious exacerbations of chronic bronchitis: diagnosis and management.; J Antimicrob Chemother; 1999 Mar; 43 Su; 97-105 |
| Sethi S; Etiology & management of infections in COPD; Clinical Pulmonary Medicine; 1999 Jan; 6(6); 327-332 |
| Sethi S;Ameen KA, Murphy TF; Mapping of monoclonal antibodies 1F5 and 2.9F to the first variable region of CopB (OMP B2) of Moraxella (Branhamella) catarrhalis. (Abstract); American Society of Microbiology Annual Meeting, Atlanta GA; 1998 May; B359; 115 |
| Sethi S;Wrona CT, Klingman KL, Murphy TF.; Serum opsonic antibody response to Moraxella (Branhamella) catarrhalis in acute exacerbations of chronic obstructive pulmonary disease (COPD). (Abstract); American Society of Microbiology Annual Meeting, Atlanta GA; 1998 May; B360; 115 |
| Sethi S;Pingle D, Klingman KL, Murphy TF.; Detection of Haemophilus DNA from culture negative sputa in COPD. (Abstract); American Thoracic Society General Meeting, Chicago IL; 1998 Apr; A58; E22 |
| Sethi S; Is chronic bronchitis an infectious disease?; Mediguide to Pulmonary Medicine; 1998; 5(1); |
| Sethi S; Management of acute exacerbations of chronic bronchitis; Infectious Diseases in Clinical Practice; 1998; 7; S300-S308 |
| Sethi S; The etiology of AECB. What role does infection play?; Postgraduate Medicine.; 1998; |
| Yi K, Sethi S, Murphy TF; Human immune response to nontypeable Haemophilus influenzae in chronic bronchitis.; J Infect Dis; 1997 Nov; 176(5); 1247-1252 |
| Sethi S, Surface JM, Murphy TF; Antigenic heterogeneity and molecular analysis of CopB of Moraxella (Branhamella)catarrhalis.; Infect Immun; 1997 Sep; 65(9); 3666-3671 |
| Bhushan R, Kirkham C, Sethi S, Murphy TF; Antigenic characterization and analysis of the human immune response to outermembrane protein E of Branhamella catarrhalis.; Infect Immun; 1997 Jul; 65(7); 2668-2675 |
| Murphy TF, Sethi S; A national strategy for research in chronic obstructive pulmonary disease. (letter); JAMA; 1997 May; 277(20); 1596-1596 |
| Sethi S;Kirkham C, Murphy TF; Human immune response to outer membrane protein E of Branhamella catarrhalis. (Abstract); American Society of Microbiology Annual Meeting, Miami Beach FL; 1997 May; B7; 30 |
| Sethi S;Ameen K, Murphy TF, Klingman KL,; Immune response to M. catarrhalis in COPD exacerbations. (Abstract); . American Thoracic Society General Meeting, San Francisco CA, May; 1997 May; A37; G32 |
| Sethi S;Muscarella KA, Murphy TF; Serum bactericidal activity for nontypeable Haemophilus influenzae (NTHI): the third factor phenomenon. (Abstract); American Society of Microbiology Annual Meeting, Miami Beach FL; 1997 May; E34; 245 |
| Sethi S;Murphy E, Muscarella KA, Murphy TF; Dynamics of respiratory tract colonization by nontypeable Haemophilus influenzae in patients with COPD. (Abstract); American Society of Microbiology Annual Meeting, New Orleans, LA; 1996 May; B178; 185 |
| Sethi S;Klingman K, Evans N, Muscarella K, Murphy TF.; Exacerbations of COPD are associated with acquisition of new strains of bacterial pathogens. (Abstract); American Thoracic Society General Meeting, New Orleans LA; 1996 May; D39; A825 |
| Sethi S., Murphy, T.F., & Klingman, K.L.; Diagnosis, epidemiology & pathogenesis of bacterial infection in the molecular era; Clinical Pathology:Molecular Pathology; 1996 Jan; 49; M1-M7 |
| Hsiao CB, Sethi S, Murphy TF; Outer membrane protein CD of Branhamella catarrhalis: sequence conservation in strains recovered from the human respiratory tract.; Microb Pathog; 1995 Oct; 19(4); 215-225 |
| Sethi S;Murphy TF; Molecular analysis of the outer membrane protein (OMP) B2 gene of Moraxella (Branhamella) catarrhalis. (Abstract); American Society of Microbiology Annual Meeting, Washington D.C.; 1995 May; B156; 192 |
| Sethi S;Evans N, Muscarella K, Klingman K, Murphy TF.; Sputum induction in stable chronic obstructive pulmonary disease (COPD): effect on sputum bacteriology. (Abstract); American Thoracic Society General Meeting, Seattle WA; 1995 May; D76; A839 |
| Sethi S, Hill SL, Murphy TF; Serum antibodies to outer membrane proteins (OMPs) of Moraxella (Branhamella)catarrhalis in patients with bronchiectasis: identification of OMP B1 as an important antigen.; Infect Immun; 1995 Apr; 63(4); 1516-1520 |
| Sethi S;Surface JM, Sethi S, DeNardin E, Murphy TF; Antigenic heterogeneity of outer membrane protein B of Moraxella (Branhamella) catarrhalis. (Abstract); American Society of Microbiology Annual Meeting, Las Vegas NV; 1994 May; D223; 135 |
| Sethi S;Murphy TF, Hill SL.; Serum antibody response to Moraxella catarrhalis in bronchiectasis. (Abstract); American Thoracic Society General Meeting, Boston MA; 1994 May; A31; A121 |
| Murphy, T.F. & Sethi,S.; Preventing or treating COPD flare-ups; Emergency Medicine; 1993 Jan; 25; 65-68 |
| Murphy TF, Sethi S; Bacterial infection in chronic obstructive pulmonary disease.; Am Rev Respir Dis; 1992 Oct; 146(4); 1067-1083 |
| Sethi S, W Sequiera; Sparing effect of hemiplegia on scleroderma.; Annals of Rheumatic Diseases; 1990 Dec; 49; 999-1000 |
GRANTS
April 2011 to April 2013
Defining the Mechanisms of the Increased Risk of Community Acquired Pneumonia in COPD Patients Treated with Inhaled Corticosteroids
Astra Zeneca
Karin Provost, Sanjay Sethi
$218,880
December 2010 to December 2012
Defining a Role for Inhaled Calcium in Augmenting the Alveolar Macrophage Innate Immune Response to Infection in COPD
Pulmatrix
Karin Provost DO, PhD; Sanjay Sethi, MD.
$115,200
September 2010 to August 2014
Bacterial Infection in COPD
VA Merit Review
Sanjay Sethi
$550,000
September 2010 to August 2013
Enhancing Nrf2 by Sulforaphane Treatment in COPD as a Novel Interventional Strategy
National Heart, Lung and Blood Institute
Sanjay Sethi
$360,000
September 2010 to August 2013
Sulforaphane Treatment in COPD as a Novel Interventional Strategy to Enhance Innate Immunity
National Heart, Lung and Blood Institute
Sanjay Sethi
$350,000
July 2010 to June 2010
A Randomized, Double-Blind, Parallel Group, Multicenter Study of the Effects of Fluticasone Propionate/Salmeterol Combination Product 250/50mcg BID in Comparison to Salmeterol 50mcg BID on the Rate of Exacerbations of COPD Following Hospitalization.
Glaxo Smith Kline
Sanjay Sethi
July 2010 to June 2013
Investigating the presence and role of biofilms in COPD and their potential contribution to exacerbations of COPD.
Astra Zeneca
Sanjay Sethi
$400,000
June 2010 to September 2010
Determination of in vitro effects of iCALM on COPD sputum.
Pulmatrix
Sanjay Sethi
July 2009 to June 2012
A six month Randomized Controlled Trial of Lung Flute in Patients with COPD
Medical Acoustics, Inc
Sanjay Sethi, Karin Provost
$210,000
December 2008 to April 2010
Phase 2, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability and Efficacy of MP-376 Inhalation Solution Administered for 5 Days Every 28 Days to prevent Acute Exacerbations in High Risk COPD Patients.
MPEX Pharmaceuticals
Sanjay Sethi
June 2008 to September 2008
A Phase 1, Multicenter, Randomized, Single-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability and Pharmacokinetics of MP-376 Solution for Inhalation Administered for 5 days to Chronic Bronchitis Patients.
MPEX Pharmaceuticals
Sanjay Sethi
January 2008 to June 2009
A Proof of Principle Randomized Controlled 8 Week Study of the Safety and Efficacy of the Lung Flute in Adults with Chronic Obstructive Pulmonary Disease a FDA 510(k) Equivalency Study.
Sanjay Sethi
July 2007 to April 2010
A Randomized, Double-Blind, Placebo Controlled, Exploratory Study to Assess the Safety and Efficacy of Multiple Doses of ACZ885 in COPD Patients.
Novartis
Sanjay Sethi
June 2007 to June 2009
A Phase IIIB twelve month, double blind, double dummy, randomized, parallel group, multi-center exacerbation study of Symbicort PMDI and 80/4.5 compared to formeterol turbohaler in COPD subjects.
Astra Zeneca Pharmaceuticals
Sanjay Sethi
June 2007 to June 2008
A Randomized, Double-Blind, Double-Dummy, Parallel Group Trial Comparing 12 Weeks Treatment with Tiotropium Inhalation Capsules 18mcg Via the HandiHaler Once Daily to Combivent Inhalation
Boehringer Ingelheim,
Sanjay Sethi
May 2007 to December 2007
Genotyping Analysis of Streptococcus pneumoniae strains isolated from the PERSPECTIVE study.
Sanofi-Aventis Pharmaceuticals
Sanjay Sethi
June 2006 to June 2007
A Prospective Observational Study for the Psychometric Validation of a Patient Reported Questionnaire in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD).
Glaxo Smith Kline
Sanjay Sethi
June 2005 to June 2008
A 6-Month Double-Blind, Double-Dummy, Randomized, Parallel Group, Multicenter Efficacy and Safety Study of Symbicort pMDI 2 X 160/4.5 ug
Astra-Zeneca
Sanjay Sethi
March 2005 to August 2010
Bacterial infection in COPD.
VA Merit Review
Sanjay Sethi
August 2004 to June 2007
A double blind, randomized, placebo controlled study to investigate intermittent pulse therapy of Moxifloxacin as a prevention of acute exacerbation of chronic bronchitis.
Bayer Pharmaceuticals
Sanjay Sethi
June 2004 to May 2005
A phase 2 placebo controlled randomized double blind study of the efficacy and safety of Tofimilast dry powder inhalation in COPD.
Pfizer
Sanjay Sethi
May 2004 to September 2004
Comparison of sputum induction with the Lung Flute with hypertonic saline and sham flute in healthy adults.
Medical Acoustics
Sanjay Sethi
January 2004 to March 2006
Comparison of sputum induction with the Lung Flute with hypertonic saline and sham flute in COPD.
Sanjay Sethi
August 2003 to July 2009
Randomized double blind trial of the effect of Advair on bacterial colonization.
Glaxo Smith Kline
Sanjay Sethi
November 2002 to September 2003
A trial of Tiotropium versus placebo assessing proportion of patients experiencing exacerbation and proportion of patients hospitalized with exacerbation of COPD.
Sanjay Sethi
May 2002 to April 2003
Comparison of sputum induction with the Lung Flute with hypertonic saline in patients with COPD.
Medical Acoustics
Sanjay Sethi
May 2002 to April 2003
Sputum induction with the Lung Flute in healthy subjects.
Medical Acoustics
Sanjay Sethi
July 2001 to April 2003
A phase 3 trial of comparative efficacy of Clarithromycin extended release and immediate release tablets in acute exacerbations of chronic bronchitis.
Boehringer Ingelheim Pharmaceuticals
Sanjay Sethi
October 2000 to March 2003
Effect of amoxicillin/clavulanate on chronic lower respiratory tract inflammation in patients with chronic bronchitis.
SmithKline Beecham Pharmaceuticals
Sanjay Sethi
October 2000 to September 2004
Enhancing clinical research at the Buffalo VA.
VA Research Enhancement
Sanjay Sethi
October 2000 to September 2004
Quality of Life assessment in acute exacerbations of COPD.
VA Research Enhancement
Sanjay Sethi
September 2000 to August 2005
Haemophilus antigen regulation of inflammation in COPD.
National Heart, Lung & Blood Institute
Sanjay Sethi
July 2000 to June 2000
Comparative study of Gemifloxacin vs Levofloxacin in acute exacerbations of chronic bronchitis.
Glaxo Smith Kline
Sanjay Sethi
July 1999 to June 2000
Comparative study of Clarithromycin extended release vs Augmentin in acute exacerbations of chronic bronchitis
Abbott
Sanjay Sethi
July 1999 to June 2000
Comparative study of Gemifloxacin vs Clarithromycin in acute exacerbations of chronic bronchitis.
Glaxo Smith Kline
Sanjay Sethi
October 1998 to September 2001
Outer membrane protein B1 of Moraxella catarrhalis.
VA Merit Review
Sanjay Sethi
October 1998 to September 2001
Quality of life in COPD: Impact of steroids and chronic inflammation.
VA Research Enhancement
Sanjay Sethi
July 1998 to May 1999
Mucosal immunity to Moraxella catarrhalis.
VA Research Enhancement
Sanjay Sethi
October 1996 to September 2000
Bacterial infection in COPD.
VA Merit Review
Sanjay Sethi
July 1995 to July 1997
Systemic corticosteroids in COPD exacerbations.
VA Cooperative Studies,
Sanjay Sethi
October 1993 to September 1996
Bacterial infection in COPD.
VA Merit Review
Sanjay Sethi
July 1993 to June 1996
Immune response to Moraxella catarrhalis in bronchiectasis.
Buswell research fellowship
Sanjay Sethi