Karl O. Yu

Karl O. A. Yu

Karl O. A. Yu MD, PhD, FAAP

UBMD Pediatrics


Immunology; Infectious Disease; Microbiology; Pediatric Infectious Diseases; Pediatrics; Virology

Accepting new patients

Professional Summary:

Like many (not so) junior academic physicians, I face the challenge in balancing my commitment to clinical medicine with the continuing development of my research career. But on reflection, I see my past training to have been as good as I could ask for. Solid postgraduate pediatric training has made me comfortable with the clinic even when I have a good fraction of my time and effort dedicated to research. On the other hand, my research training has ranged from microbiology/immunology work in cells, mice, and guinea pigs, through study logistics, patient recruitment, and data management in clinical research. These are tools necessary in my continuing work as a physician, scientist, and educator.

My research interests remain in the host/pathogen relationship. This is where one needs a practical knowledge of both immunology and microbiology applied onto the same problem, with potential applications to clinical infectious disease. I have made contributions in this field with relation to influenza, Staphylococcus aureus, and Legionella pneumophila. Before coming to Buffalo, I’ve gained experience on pediatric field studies and microbiologic epidemiology of pediatric acute otitis media.

Here in Buffalo, I take care of children with proven or suspected infection inpatient in Oishei Children's Hospital and outpatient in UBMD Pediatrics in the Conventus building. I have responsibilities in infection prevention in Oishei Children's Hospital, as well. My scholarly work entails investigations in bacteriophage and in hepatitis C, in collaboration with Dr. Oscar Gomez (Pediatric Infectious Disease / CTRC). My clinical interests rests with infections in the immunocompromised host, and in primary immunodeficiencies. I value my clinical work with our many patients and their physicians -- but do particularly enjoy my work with my colleagues in Allergy & Immunology and Hematology / Oncology / Stem Cell Transplantation. Outside of Buffalo, I am most active in the Pediatric Infectious Diseases Society and the Clinical Immunology Society.

My most important job, I believe, remains in what my ex-chief has told me it would be in -- this is in "training your own replacement." Since finishing medical school, I have helped train -- and have learned from -- nurses, lab scientists, medical and graduate students, residents, and infectious disease fellows. I consider it a continuing privilege for me to contribute to the pediatric infectious disease and immunology education of the next generation of physicians and scientists, and the main reason I choose to remain in academic pediatric medicine.


Immunology, Infectious Disease, Microbiology, Pediatric Infectious Diseases, Pediatrics, Virology

Patients Treated:

Children, Adolescents

Physician Gender:



UBMD Pediatrics Outpatient Center
UBMD Pediatrics - Conventus Building
1001 Main Street
4th Floor
Buffalo, New York 14203
Office Hours: Tuesday: 8:00 am-12:00 pm; Wednesday: 1:00 pm-5:00 pm
Phone: (716) 323-0150
Fax: (716) 323-0296
Accepting new patients

Insurance Accepted:
  • Aetna U.S. Healthcare
  • Blue Cross & Blue Shield of WNY Inc
  • CIGNA HealthCare
  • Community Blue (HMO)
  • Community Blue Advantage
  • Coventry
  • Empire
  • Fidelis
  • Independent Health Association (HMO)
  • Independent Health Medisource
  • Lifetime Benefit Solutions / RMSCO
  • MVP Healthcare
  • Magnacare
  • Medicaid
  • Medicare
  • Nofault
  • North American Administrators
  • Nova
  • Preferred Care
  • Railroad Medicare
  • TriCare/Champus
  • Tricare
  • United Healthcare
  • Univera Health Care (HMO)
  • Veterans Administration
  • WellCare
  • Workers Comp

Board Certifications:

  • Board Certification, American Board of Pediatrics
  • Board Certification, American Board of Pediatrics, Sub-board in Pediatric Infectious Diseases

Education and Training:

  • Fellowship, Pediatric Infectious Diseases, University of Chicago Medical Center (2014)
  • Residency, General Pediatrics, Cohen Children‘s Medical Center of New York, Hofstra/Northwell Health (formerly North Shore LIJ Health System) (2011)
  • Internship, General Pediatrics, Cohen Children‘s Medical Center of New York, Hofstra/Northwell Health (formerly North Shore LIJ Health System) (2009)
  • MD, Medicine, Albert Einstein College of Medicine of Yeshiva University (2008)
  • PhD, Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University (2008)
  • MS, Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University (2002)
  • BA, Biochemistry; Mathematics (minor), Hiram College, Summa Cum Laude (2000)
  • Other, Jerome K. Lemelson Fellowship, Hampshire College (1998)

Awards and Honors:

  • Buffalo Spree Magazine: Top Doctors in Western New York (2022)
  • Buffalo Spree Magazine: Top Doctors in Western New York (2021)
  • Buffalo Spree Magazine: Top Doctors in Western New York (2020)
  • Castle Connolly Medical Ltd: America‘s Top Doctors (2020)
  • University of Chicago Pediatric Research Day: Research Poster Award for Junior Faculty (Translational Research) (2016)
  • Clinical Immunology Society Annual Meeting: Travel Grant (2015)
  • ID Week: Travel Grant (2014)
  • Pediatric Infectious Diseases Society: Pediatric Fellow Poster Award (2014)
  • St. Jude Children‘s Research Hospital/Pediatric Infectious Diseases Society Research Conference: Travel Grant (2014)
  • Clinical Immunology Society School of Primary Immunodeficiencies: Travel Grant (2013)
  • Midwest AIDS Training and Education Center: MATEC Clinical Scholar (2012-2013) (2012)
  • Hiram College Department of Mathematics: Kenneth M. Hiney Mathematics Award (2000)
  • Hiram College Department of Biology: J.J. Turner Society Member (2000)
  • Albert Einstein College of Medicine Summer Undergraduate Research Program: Stipend (1999)
  • Hampshire College: Visiting Jerome K. Lemelson Fellowship (1998)
  • Hiram College: Vencl-Carr Research Assistantship (1998)
  • Hiram College Department of Biology: Paul Smey Award (1998-2000) (1998)
  • Hiram College: Alpha Society (1997-2000) (1997)
  • Hiram College: Dean‘s List (1997-2000) (1997)
  • Consortium for Mathematics and Its Applications/Mathematical Association of America: Mathematical Competition on Modeling - Honorable Mention (1997, 2000) (1997)
  • Hiram College: Trustees Global Scholar (1996-2000) (1996)
  • 37th International Mathematical Olympiad: National Delegate (1996)
  • Philippine Mathematical Olympiad: First Place (1995)

Research Profile:

This UBMD physician is also a member of the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, teaching the next generation of doctors and researching to advance care in WNY and beyond. Learn more about this physician's research and teaching activities, as well as view credentials, publications, professional involvement and more below.

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