Umesh Sharma

Umesh Sharma
M.D., Ph.D.

Umesh Sharma M.D., Ph.D.

UBMD Internal Medicine


Cardiac pharmacology; Cardiology; Cardiovascular Disease; Drug Development; Gene Expression; Inflammation; Internal Medicine; Preclinical MRI; Radiation Oncology; Translational imaging

Hospital-based provider only

Professional Summary:

I am a cardiologist with specialized training in advanced cardiac imaging. I see outpatients at the Heart and Lung Center of Buffalo General Medicine Center (BGMC), and I care for inpatients through the cardiology consult and inpatient services at BGMC. As an advanced imaging cardiologist, I am responsible for developing and advancing the cardiac computed tomography (CT) and magnetic resonance imaging (MRI) programs at the Gates Vascular Institute (GVI) and providing these services to patients. These advanced, noninvasive imaging techniques allow physicians to perform in-depth, 3-D evaluation of the coronary tree, myocardium, heart valves, pericardium and great vessels. These imaging tools allow for the best possible diagnoses and care of patients.

My research spans basic science, translational and clinical fields and combines the cross-discipline expertise on magnetic resonance (MR) technology with molecular biology. My overall goal is to study the consequences of ischemia-induced myocardial injury, with a focus on their therapeutic reversal. My research laboratory at UB’s Clinical and Translational Research Center (CTRC) is devoted to the development of novel time-and-tissue-targeted MRI methods for integrative understanding of cardiovascular pathophysiology in preclinical models. We have several interesting research projects, e.g., we have recently discovered that the presence of high-risk plaques in the carotid arteries predict future incidence of myocardial infarction and stroke. The results emphasize that the nature of atherosclerosis and the use of comprehensive non-invasive computed tomography angiography (CTA) will help identify patients who are at higher risk of developing ischemic stroke. These research results will help physicians employ early therapeutic strategies for these high-risk patients.

I mentor medical students, residents and fellows both in clinical and research settings, and I precept cardiology fellows at the Heart and Lung Center at BGMC. In addition, I am deeply engaged in furthering the research and clinical education of our house staff. Our trainees have published their research in highly esteemed peer-reviewed journals, and many have routinely presented their work at national and international scientific conferences. I am committed to facilitating the career goals of my mentees while I continue to advance my own career as a clinician, researcher and mentor.


Cardiac pharmacology, Cardiology, Cardiovascular Disease, Drug Development, Gene Expression, Inflammation, Internal Medicine, Preclinical MRI, Radiation Oncology, Translational imaging

Patients Treated:

Adults, Seniors/Elderly

Additional Languages:

Intermediate Hindi, Fluent Nepali

Physician Gender:


Hospital Locations (for inpatients only):

  • Buffalo General Medical Center

Education and Training:

  • Fellowship, Advanced Cardiac Imaging, Massachusetts General Hospital (2013)
  • Fellowship, Cardiovascular Medicine, University of Louisville (2012)
  • Residency, Internal Medicine, Chicago Medical School (2009)
  • PhD, Molecular mechanisms of heart failure, University of Maasricht (2005)
  • MS, Medical Immunology, University of London (2002)
  • , Tribhuvan University (2000)

Awards and Honors:

  • Annual Meeting of the Central Society for Clinical and Translational Research-Travel Award (2018)
  • Emerging Investigator: Circulation Heart Failure (2018)
  • Outstanding Resident (2009)
  • Professionalism Award (2009)

Research Profile:

This UBMD physician is also a member of the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, teaching the next generation of doctors and researching to advance care in WNY and beyond. Learn more about this physician's research and teaching activities, as well as view credentials, publications, professional involvement and more below.

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